Research in the Franke Group

Biochemistry of plant specialised metabolites

We study how plants make complex natural products with medicinal properties. For this, we use a combination of chemical, molecular biological, biochemical, plant biological and bioinformatics methods. Our aim is to understand the molecular mechanisms underlying plant biosynthetic pathways and translate this knowledge into better exploitation of valuable plant compounds.

Biochemistry of plant specialised metabolites

We study how plants make complex natural products with medicinal properties. For this, we use a combination of chemical, molecular biological, biochemical, plant biological and bioinformatics methods. Our aim is to understand the molecular mechanisms underlying plant biosynthetic pathways and translate this knowledge into better exploitation of valuable plant compounds.

Two centrals questions drive our research:

  1. Pathway Elucidation: How do plants make complex natural products? Which genes and enzymes are required? What are the chemical mechanisms involved? How is the formation orchestrated across multiple types of cells and tissues?
  2. Metabolic Engineering: How can we manipulate plant biosynthetic pathways in a targeted manner? How can we generate larger quantities of rare natural products? How can the product profile be changed? Can we generate analogues of natural products in biological systems, which are otherwise only accessible by total synthesis?

CONTACT

Prof. Dr. rer. nat. Jakob Franke
Address
Herrenhäuser Straße 2
30419 Hannover
Prof. Dr. rer. nat. Jakob Franke
Address
Herrenhäuser Straße 2
30419 Hannover