Publikationen der Arbeitsgruppe Biochemie sekundärer Pflanzenstoffe

Prof. Dr. Jakob Franke


  • Chuang, L., Liu, S., Franke, J. (2023): Post-Cyclization Skeletal Rearrangements in Plant Triterpenoid Biosynthesis by a Pair of Branchpoint IsomerasesJournal of the American Chemical Society 145:5083–5091
  • Freke, R., Heinemann, B., Hakim, S.E., Witte, C.-P., Herde, M., Hildebrandt, T.M., Franke, J. (2023): Isotope-guided metabolomics reveals divergent incorporation of valine into different flavor precursor classes in chivesChemBioChem e202300056
  • Kwan, B.D., Seligmann, B., Nguyen, T.-D., Franke, J., Dang, T.-T.T. (2023): Leveraging synthetic biology and metabolic engineering to overcome obstacles in plant pathway elucidationCurrent Opinion in Plant Biology 71:102330.
  • Malhotra, K., Franke, J. (2023): Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plantsBeilstein Journal of Organic Chemistry 18:1289–1310
  • Chuang, L., Enders, A., Offermann, S., Bahnemann, J., Franke, J. (2023): 3D-printed autoclavable plant holders to facilitate large-scale protein production in plantsEngineering in Life Sciences 22:803–810
  • Chuang, L.; Liu, S.; Biedermann, D.; Franke, J. (2022): Identification of early quassinoid biosynthesis in the invasive tree of heaven (Ailanthus altissima) confirms evolutionary origin from protolimonoids.Frontiers in Plant Science 13:958138
  • Franke, J.; Zhang, Y.; Dang, T.-T. T. (2022): Editorial: Exploring and Engineering Plant Specialized Metabolism: Latest Advances and New Horizons.Frontiers in Plant Science, 12: 783465
    DOI: 10.3389/fpls.2021.783465
  • Chuang, L.; Franke, J. (2022): Rapid Combinatorial Coexpression of Biosynthetic Genes by Transient Expression in the Plant Host Nicotiana Benthamiana.Engineering Natural Product Biosynthesis: Methods and Protocols; Skellam, E., Ed.; Methods in Molecular Biology; Springer US: New York, NY, 2022; pp. 395–420
    DOI: 10.1007/978-1-0716-2273-5_20
  • Caputi, L.*; Franke, J.*; Bussey, K.; Farrow, S. C.; Vieira, I. J. C.; Stevenson, C. E. M.; Lawson, D. M.; O’Connor, S. E (2020): Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloidsNat Chem Biol
    DOI: 10.1038/s41589-019-0460-x
  • Trottmann, F.; Ishida, K.; Franke, J.; Stanišić, A.; Ishida‐Ito, M.; Kries, H.; Pohnert, G.; Hertweck, C. (2020): Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence FactorAngew Chem Int Ed
    DOI: 10.1002/anie.202003958
  • Trottmann, F.; Franke, J.; Richter, I.; Ishida, K.; Cyrulies, M.; Dahse, H.-M.; Regestein, L.; Hertweck, C. (2019): Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human‐ and Animal‐Pathogenic Burkholderia SpeciesAngew. Chem. Int. Ed. 2019, 58, 14129–14133
    DOI: 10.1002/anie.201907324
  • Franke, J.; Kim, J.; Hamilton, J. P.; Zhao, D.; Pham, G. M.; Wiegert-Rininger, K.; Crisovan, E.; Newton, L.; Vaillancourt, B.; Tatsis, E.; Buell, C. R., O’Connor, S. E. (2019): Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesisChemBioChem, 2019, 20, 83–87
    DOI: 10.1002/cbic.201800592
  • Stein, A.; Compera, D.; Karge, B.; Brönstrup, M.; Franke, J. (2019): Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.Beilstein J. Org. Chem. 2019, 15, 2003–2012
    DOI: 10.3762/bjoc.15.196
  • Trottmann, F.;* Franke, J.;* Ishida, K.; García-Altares M.; Hertweck, C. (2019): A Pair of Bacterial Siderophores Releases and Traps an Intercellular Signal Molecule: An Unusual Case of Natural Nitrone BioconjugationAngew. Chem. Int. Ed. 2019, 58, 200–204
    DOI: 10.1002/anie.201811131
  • Caputi, L.; Franke, J.; Farrow, S.C.; Chung, K.; Payne, R.M.E.; Nguyen, T.-D.; Dang, T.-T.T.; Carqueijeiro, I.S.T.; Koudounas, K.; de Bernonville, T.D.; Ameyaw, B.; Jones, D.M.; Curcino Veira, I.J.; Courdavault, V.; O'Connor, S.E. (2018): Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkleScience 2018, 360, 1235–1239.
    DOI: 10.1126/science.aat4100
  • Dang, T.-T.T.*; Franke, J.*; Carqueijeiro, I.S.T.; Langley, C.; Courdavault, V.; O'Connor, S.E. (2018): Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modesNat. Chem. Biol. 2018, 14, 760–763.
    DOI: 10.1038/s41589-018-0078-4
  • Dang, T.T. , Franke, J., Tatsis, E., O’Connor, S.E. (2017): Dual Catalytic Activity of a Cytochrome P450 Controls Bifurcation at a Metabolic Branch Point of Alkaloid Biosynthesis in Rauwolfia serpentinaAngew. Chem. Int. Ed. 2017, 56, 9440–9444.
    DOI: 10.1002/anie.201705010
  • Tatsis, E.*, Carqueijeiro, I.*, Dugé de Bernonville, T., Franke, J., Dang, T.T., Oudin, A., Lanoue, A., Lafontaine, F., Stavrinides, A.K., Clastre, M., Courdavault, V., O’Connor, S.E. (2017): A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediateNat. Commun. 2017, 8, 316.
    DOI: 10.1038/s41467-017-00154-x
  • Franke, J.; Hertweck, C. (2016): Biomimetic Thioesters as Probes for Enzymatic Assembly Lines: Synthesis, Applications, and Challenges (Review)Cell Chem. Biol. 2016, 23, 1179–1192­.
    DOI: 10.1016/j.chembiol.2016.08.014
  • Baunach, M.; Franke, J.; Hertweck, C. (2015): Terpenoid Cyclizations Off the Beaten Track (Review)Angew. Chem. Int. Ed. 2015, 54, 2604–2626.
    DOI: 10.1002/anie.201407883
  • Ding, L.; Franke, J.; Hertweck, C. (2015): Divergolide congeners illuminate alternative reaction channels for ansamycin diversificationOrg. Biomol. Chem. 2015, 13, 1618–1623.
    DOI: 10.1039/c4ob02244k
  • Franke, J.; Ishida, K.; Hertweck, C. (2015): Plasticity of the malleobactin pathway and its impact on siderophore action in human pathogenic bacteriaChem. Eur. J. 2015, 21, 8010–8014.
    DOI: 10.1002/chem.201500757
  • Franke, J.*; Ishida, K.*; Hertweck, C. (2014): Evolution of Siderophore Pathways in Human Pathogenic BacteriaJ. Am. Chem. Soc. 2014, 136, 5599–5602.
    DOI: 10.1021/ja501597w
  • Xu, Z.; Baunach, M.; Ding, L.; Peng, H.; Franke, J.; Hertweck, C. (2014): Biosynthetic Code for Divergolide Assembly in a Bacterial Mangrove EndophyteChemBioChem 2014, 15, 1274–1279.
    DOI: 10.1002/cbic.201402071
  • Franke, J.*; Ishida, K.*; Ishida-Ito, M.; Hertweck, C. (2013): Nitro versus hydroxamate in siderophores of pathogenic bacteria: effect of missing hydroxylamine protection in malleobactin biosynthesisAngew. Chem. Int. Ed. 2013, 52, 8271–8275.
    DOI: 10.1002/anie.201303196
  • Franke, J.*; Ishida, K.*; Hertweck, C. (2012): Genomics‐Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human Pathogenic Burkholderia SpeciesAngew. Chem. Int. Ed. 2012, 51, 11611–11615
    DOI: 10.1002/anie.201205566